All Year All Shedding light on biology and healthcare—preface to the special issue on Biomedical Optics This special issue collects 20 excellent papers, spanning NIR II imaging, high-speed imaging, adaptive wavefront shaping, label-free imaging, ultrasensitive detection, polarization optics, photodynamic therapy, and preclinical applications. Peng XiXunbin WeiValery V. Tuchin Editorial Open Access 02 Jun 2022 Transport of intensity diffraction tomography with non-interferometric synthetic aperture for three-dimensional label-free microscopy Jiaji LiNing ZhouChao Zuo Article Open Access 02 Jun 2022 Enhancing spatiotemporal focusing of light deep inside scattering media with Time-Gated Reflection Matrix Zhipeng YuHuanhao LiPuxiang Lai News & Views Open Access 01 Jun 2022 Evidence for moiré intralayer excitons in twisted WSe2/WSe2 homobilayer superlattices The moiré intralayer excitons in the twisted WSe2/WSe2 homobilayers superlattices were successfully observed and confirmed the existence of moiré intralayer excitons. Biao WuHaihong ZhengYanping Liu Article Open Access 01 Jun 2022 Metamaterial-enabled arbitrary on-chip spatial mode manipulation Jinlong XiangZhiyuan TaoYikai Su Article Open Access 01 Jun 2022 Mid-infrared III–V semiconductor lasers epitaxially grown on Si substrates Eric TourniéLaura Monge BartolomeJean-Baptiste Rodriguez Review Article Open Access 01 Jun 2022 Discrimination of circular polarized light Guangbo QuGuibin Jiang Research Highlight Open Access 30 May 2022 Graphene-driving novel strain relaxation towards AlN film and DUV photoelectronic devices Graphene-driving strain-pre-store engineering enables the epitaxy of strain-free AlN film with low dislocation density for high efficiency DUV-LEDs. Hieu. P. T. Nguyen News & Views Open Access 30 May 2022 Intrinsic superflat bands in general twisted bilayer systems Hongfei WangShaojie MaDangyuan Lei Article Open Access 30 May 2022 Advanced liquid crystal devices for augmented reality and virtual reality displays: principles and applications Advanced liquid crystal-based light engines and planar optical components play pivotal roles for systematically improving the image quality and formfactor of the augmented reality and virtual reality displays. Kun YinEn-Lin HsiangShin-Tson Wu Review Article Open Access 30 May 2022 Halogen-doped phosphorescent carbon dots for grayscale patterning Yanfeng LiuMahmoud Al-salihiJunle Qu Article Open Access 30 May 2022 Highly efficient green InP-based quantum dot light-emitting diodes regulated by inner alloyed shell component In this work, the pure green-emitting InP/ZnSexS1−x/ZnS quantum dots and their light-emitting diodes with high efficiency were successfully obtained by regulating the components of inner alloyed shell ZnSexS1−x layer. Peng YuSheng CaoJialong Zhao Article Open Access 30 May 2022 Bringing chiral functionality to in vivo applications of nanomaterials Maria Mukhina News & Views Open Access 27 May 2022 Metasurface-enabled on-chip multiplexed diffractive neural networks in the visible A polarization-multiplexed metasurface-enabled diffractive neural network, which is integrated with a CMOS imaging sensor, demonstrates on-chip multi-channel sensing and multitasking in the visible. Xuhao LuoYueqiang HuHuigao Duan